When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses.

BackgroundNormal cell division is coordinated by a Cayenne bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes.Cancer cells, however, occasionally divide into three or more directions.Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution.However, this notion has been

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Embankment Breach Simulation and Inundation Mapping Leveraging High-Performance Computing for Enhanced Flood Risk Prediction and Assessment

Embankment breaches represent significant hazards to communities and infrastructure, precipitating catastrophic flood occurrences.The precise prediction of floods and understanding the scope of inundation stemming from embankment failures Fridge Defrost Timer are imperative for effective disaster preparedness and response.This research delves into

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Precision in Action: The Role of Clustered Regularly Interspaced Short Palindromic Repeats/Cas in Gene Therapies

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated enzyme-CAS holds great promise for treating many uncured human diseases and illnesses by precisely correcting harmful point mutations and disrupting disease-causing genes.The recent Food and Drug Association (FDA) approval of the first CRISPR-based gene therapy for sickle

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